Research Projects and Methods
Molecular classification of Adrenocortical tumors
a project in cooperation with the MET-study center (Prof. Dr. Michaela Kuhlen, PD Dr. Antje Redlich)- using methylation based classification and single cell approaches, we develop a molecular based subgrouping of ACT and dicern biological differences of the subgroups
The enhancer landscape of epithelioid sarcoma
By comparing the epigenetic landscape of rhabdoid tumors and epitheliod sarcoma, we seek to unravel communlaities and differences between rhabdoid tumors.
In collaboration with the labs of Prof. Grünewald (KiTZ Heidelberg) and the CWS registry (Prof. Sparber-Sauer), we ultimately aim to unravel novel drug targets.
Spatial and single cell transcriptomics in rhabdoid tumors
In a cooperative project with the INFORM registry, we have performed a paired analysis of primary-relapse Rhabdoid tumors and are thus tracking the molecular evolution of these tumors upon relapse (Project: Maria Daniela Hernández Ramírez)
Rare embryonal/sarcomatous brain tumors
As one of the co-leads of the German study group for rare embryonal/sarcomatous brain tumors, Pascal Johann is active both in the molecular study of these tumors but aso in establishing clinical guidelines of these difficult to treat tumor entities
Radiation sensitivity of SWI/SNF deficient diseases
(mock image) using conventional and hyperfractionated radiotherapy, we determine the radiosensitivity of numerous models of Rhabdoid tumors, small cell carcinoma of the ovary (hyerpcalecmic type) and epithelioid sarcomas (projects: Rebekka Prim, Svenja Steinhauser)